Phospholipase C epsilon 1 (PLCE1) (NM_001165979) Human 3' UTR Clone

Specifications

Product Data
Product Name	Phospholipase C epsilon 1 (PLCE1) (NM_001165979) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	NPHS3; PLCE; PPLC
ACCN	NM_001165979
Insert Size	492 bp
Sequence Data	Insert Sequence (showhide) >SC206071 3’UTR clone of NM_001165979 The sequence shown below is from the reference sequence of NM_001165979. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCAGTGACACAATGGATTACCGACAGTGACTAAGGGCAGCATGTTTAACCCAGGTGAAGATCTTTAAG CAAGAAGTTAAAGAGTGAACATGGTGGAAAAAATATAATTATTTTCATCAGACTTAAACTGGAAATTGA TGATTTCTGAACTGAAGCCTTCACACATGTGAGATCCATGCTGAGGAGAAGCAAAATGGCACAGGGCTA GTTGCCACCAACCAATTTACTGATGAATGAAGCCCAGGGGACTGCCATTTTATAAATGTCAGCAGTTGG AAAAATCGTCACGAATTGACTTAGAGCAAGGGTCAGCAAGCTTGTCTGTAAAGGGCCAAACAGTAAATA TTTTAGGGCTGGGGGCCATAAAATATGTTGCAACCACCCAATTCTGCCATTGTAGTGCAAAAGCAGCCA TAGACAACACATACATGAACGAACGTGGCTGTATTCCAATAAAACTTTATTTATGGACACTGAAAAAAA AAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001165979.2
Synonyms	NPHS3; PLCE; PPLC
Summary	This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Locus ID	51196
MW	19

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