ATF6 (NM_007348) Human 3' UTR Clone

Specifications

Product Data
Product Name	ATF6 (NM_007348) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ACHM7; ATF6A
ACCN	NM_007348
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC205479 3’UTR clone of NM_007348 The sequence shown below is from the reference sequence of NM_007348. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCAGCACCATCCCTGAGTCATTACAATAGCACCCTGCAGCTATGCTGGAAAACTGAGCGTGGGACCCT GCCAGACTGAAGAGCAGGTGAGCAAAATGCTGCTTTCTGCCTTGGTGGCAGGCAGAGAACTGTCTCGTA CTAGAATTCAAGGAGGAAAGAAGAAGAAATAAAAGAAGCTGCTCCATTTTTCATCATCTACCCATCTAT TTGGAAAGCACTGGAATTCAGATGCAAGAGAACAATGTTTCTTCAGTGGCAAATGTAGCCCTGCATCCT CCAGTGTTACCTGGTGTAGATTTTTTTTTCTGTACCTTTCTAAACCTCTCTTCCCTCTGTGATGGTTTT GTGTTTAAACAGTCATCTTCTTTTAAATAATATCCACCTCTCCTTTTTGCCATTTCACTTATTGATTCA TAAAGTGAATTTTATTTAAAGCTATGCCACACATGCATGTTCAAATGGTTTCCACTGATTCGATTTTTC ATTCATTTAATGCAAACCCATTCTGGATATTGTGCTTATTTGAGAAAACACATTTCAAAACCAGAAAAG CCAAAAACACTCCAAAAACAAGCAAAACAATTTGGAGCTTTAGATAAAAGGAAAAACTCCCAGTTGGTA AAGTTTATCTTTACTTAGGATTTGTGGCTCACACCTAAACAAAGGGGGTCAGGGAGTGGGTACAAATTT GAGAAAATAGAAGGGTAAGGGAAGGGCCAGTGGTGGGGTTTGGAGAGAGGAGATAGCTCCATTAATACA CATGTTTAAAAGATGGAAAGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAC GAGGTCAGGAGATCAAGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAT TAGCCGGGCGTAGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGA ACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAG ACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGATGGAAAGTTCGATGTGACTGCAGTATGAGATT AAAGCCACAACTATTGTTTATTTTGGGGACTCTAGGCCACCAAGTATTAGCACACATACTTATGTTTTC TCTACTAATCTGGTCCAGGTCCTCATGGACCACAGGACAAAGCTTTCATTTTCATTCATTCTTCTATTG AAATTATACCAAATTCAGCTGAGGAATATGGAAGTAACTTTAGACTTAAACAAGACAAAAGTTTTTTCA CTGAAGAATTGACAAGTATTTGCTCCTTAAAACAACGCAGATTAGTGAACGTGGATTCCTGCTGAGGGA GTGCATCCCATAATATGGCAATAATTTTCAGTTTCTCCAACGAAAAGATAGTGAAGGAATTAAATCTTT TGTCCTCCCATGGTTAAAAAAAAAAAAAAAGCTGTGTTCATTTTTACTGTACTATGCCTCTTTTTTCAC CATAGTAGACAATTATGTTTCATTTGATGAATTCATAGAACTGGATCTCATACAGCGATGTCCTCTCTA ATGTTCTACCTTTCAGTTTCTAAAGTGAGTCTTCCTCCCTCTCCTACAAAACTTTTCAATTTTTTGATG TAACTCATCTACAAATACTGTTTCTTACCCCAGTTGACTTGCCTTTGTCAGATTTCTTCTTGTTCCACA CTATAGCAATCAATTTCTCTTCTTCCTTACAAGAAAGGGAACGAGAAATTGTAGCAACCTCTCAAGGAT TATATGCAGCTAGTTAGTTTTCTGCCTGTGAAATTAGGTCTGGCTCCTAAATAATTTTAAAGAACCATC AGCACTTCTAACTCTCTGGACAGGTGCCTCTTTGTCCAAGCTAGTTAAATGCTTTCCAAGGAAATCAGT TCAACTTTTGTGAGCGGGGAAAAGCAGGGCTTTATTGTTGTGTTACCTGGGAGTCTGGAGTTTGAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_007348.4
Synonyms	ACHM7; ATF6A
Summary	This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Locus ID	22926
MW	76.3

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