FMO3 (NM_001002294) Human 3' UTR Clone

Specifications

Product Data
Product Name	FMO3 (NM_001002294) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	dJ127D3.1; FMOII; TMAU
ACCN	NM_001002294
Insert Size	407 bp
Sequence Data	Insert Sequence (showhide) >SC205330 3’UTR clone of NM_001002294 The sequence shown below is from the reference sequence of NM_001002294. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCTAGGATTTCTGAAAGTTACTGACAAT ACCCAGACAGGGGCTTTGCTATTTAAAAATTAAAATTTTCACACCACCTGCTTTTCTATTCAGCATCTT TTGCAGTACTCTGTAGACATTAGTCAGTAATACAGTGTTATTTCTAGGCTCTGAAATAGCCACTTTAAG AATCATGTCATGATCTTAAGAGAGCACTAATCATTTCTGTTTGAGTTCCACTAACACTTCAAAATCAGA ACTATGTTCTTTATATCTAACTTAAATCATTTCCTGAAACATTTTGACATGATTCCTTTTTCCTTTTAA ACAATGTATGAAAGATGTATTTTAAATCTAAATAAAGAGCAAATTAAGCAGAATAATTATAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001002294.3
Synonyms	dJ127D3.1; FMOII; TMAU
Summary	Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Locus ID	2328
MW	16.1

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