HLA-DQB1 (NM_002123) Human 3' UTR Clone

Specifications

Product Data
Product Name	HLA-DQB1 (NM_002123) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CELIAC1; HLA-DQB; IDDM1
ACCN	NM_002123
Insert Size	799 bp
Sequence Data	Insert Sequence (showhide) >SC205037 3’UTR clone of NM_002123 The sequence shown below is from the reference sequence of NM_002123. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAAAGGAGTCAGAAAGGGCTTCTGCACTGACTCCTGAGACTATTTTAACTAGGATTGGTTATCACTCTT CTGTGATGCCTGCTTATGCCTGCCCAGAATTCCCAGCTGCCTGTGTCAGCTTGTCCCCCTGAGATCAAA GTCCTACAGTGGCTGTCACGCAGCCACCAGGTCATCTCCTTTCATCCCCACCCCAAGGCGCTGGCTGTG ACTCTGCTTCCTGCACTGACCCAGAGCCTCTGCCTGTGCATGGCCAGCTGCGTCTACTCAGGTCCCAAG GGGTTTCTGTTTCTATTCTTTCCTCAGACTGCTCAAGAGAAGCACATGAAAAACATTACCTGACTTTAG AGCTTTTTTACATAATTAAACATGATCCTGAGTTATCTGTATTCTGAACTTTCTTAATTGAGAAGAGGC AGGAAATCACTGCAGAATGAAGGAACATCCCTTGAGGTGACCCAGCAAACCTGTGGCCAGAAGGAGGAT TGTACCTTGAAAAGACACTGAAAGCATTTTGGGGTGTGAAGTAAGGGTGGGCAGAGGAGGTAGAAAATA ATTCAATTGTCGCATCATTCATGGTTCTTTAATACTGATGCTCAGTGCATTGGCCTTAGAATATCCCAG CCTCTCTTCTGGTTTGGTGAGTGCTGTGTAAATAAGCATGGTAGAATTGTTTGGAGACATATATAGTGA TCCTTGGTCACTGGTGTTTCAAACATTCTGGAAAGTCACATCGATCAAGAATATTTTTTATTTTTAAGA AAGCATAACCAGCAATAAAAATACTATTTTTGAGTCTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002123.5
Synonyms	CELIAC1; HLA-DQB; IDDM1
Summary	HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Locus ID	3119
MW	30.6

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