C11orf73 (HIKESHI) (NM_016401) Human 3' UTR Clone

Specifications

Product Data
Product Name	C11orf73 (HIKESHI) (NM_016401) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C11orf73; HLD13; HSPC138; HSPC179; L7RN6; OPI10
ACCN	NM_016401
Insert Size	335 bp
Sequence Data	Insert Sequence (showhide) >SC204768 3’UTR clone of NM_016401 The sequence shown below is from the reference sequence of NM_016401. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCACAGAACCCTCTCTTTTGGAAAACATAATTTGAATAAAATAATTTTTAATGGATTCTGAAATTTGTC ATGTTTTGAAGATAACTGACTCCATCTAAAAGTATGAGGTCAAAGGATCACGAAACCTAAGTTTAAAAA CTGCTTAGAGACTGAAGCTTAATTAAAAATCTTTATTAAAAATTAAAAACATTGAAAAATGAAAATATG TTCATCATTAAAGACTTTTTTCCCCTTAAGCTTAAAATACCATTCAAAGGCAAGACATTTTGTTTTGGC TATGATTCATTTTTTTTACTTAAAAATAAAACCTATACCAAACAGTAGTGTGCCAAGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_016401.4
Synonyms	C11orf73; HLD13; HSPC138; HSPC179; L7RN6; OPI10
Summary	This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
Locus ID	51501
MW	13.4

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