Topoisomerase II beta (TOP2B) (NM_001068) Human 3' UTR Clone

Specifications

Product Data
Product Name	Topoisomerase II beta (TOP2B) (NM_001068) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	top2beta; TOPIIB
ACCN	NM_001068
Insert Size	449 bp
Sequence Data	Insert Sequence (showhide) >SC204287 3’UTR clone of NM_001068 The sequence shown below is from the reference sequence of NM_001068. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATGATGTTGATTTTGCAATGTTTAATTAAGTGCCCAAAGAGCACAAACATTTTTCAACAAATATCTTG TGTTGTCCTTTTGTCTTCTCTGTCTCAGACTTTTGTACATCTGGCTTATTTTAATGTGATGATGTAATT GACGGTTTTTTATTATTGTGGTAGGCCTTTTAACATTTTGTTCTTACACATACAGTTTTATGCTCTTTT TTACTCATTGAAATGTCACGTACTGTCTGATTGGCTTGTAGAATTGTTATAGACTGCCGTGCATTAGCA CAGATTTTAATTGTCATGGTTACAAACTACAGACCTGCTTTTTGAAATGAAATTTAAACATTAAAAATG GAACTGTGTTCTCTGTCTCTTTACTGAAGATAAAGGTGTAGTAAAAGCTCCCACACACCTTTAAAATAA ATATATTTTATTCTTTGCAAAAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001068.3
Synonyms	top2beta; TOPIIB
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Locus ID	7155
MW	17.2

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