MEK2 (MAP2K2) (NM_030662) Human 3' UTR Clone

Specifications

Product Data
Product Name	MEK2 (MAP2K2) (NM_030662) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CFC4; MAPKK2; MEK2; MKK2; PRKMK2
ACCN	NM_030662
Insert Size	307 bp
Sequence Data	Insert Sequence (showhide) >SC203958 3’UTR clone of NM_030662 The sequence shown below is from the reference sequence of NM_030662. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCGGCACACCCACGCGCACCGCCGTGTGACAGTGGCCGGGCTCCCTGCGTCCCGCTGGTGACCTGCCC ACCGTCCCTGTCCATGCCCCGCCCTTCCAGCTGAGGACAGGCTGGCGCCTCCACCCACCCTCCTGCCTC ACCCCTGCGGAGAGCACCGTGGCGGGGCGACAGCGCATGCAGGAACGGGGGTCTCCTCTCCTGCCCGTC CTGGCCGGGGTGCCTCTGGGGACGGGCGACGCTGCTGTGTGTGGTCTCAGAGGCTCTGCTTCCTTAGGT TACAAAACAAAACAGGGAGAGAAAAAGCAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_030662.4
Synonyms	CFC4; MAPKK2; MEK2; MKK2; PRKMK2
Summary	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Locus ID	5605
MW	10.7

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