p107 (RBL1) (NM_183404) Human 3' UTR Clone

Specifications

Product Data
Product Name	p107 (RBL1) (NM_183404) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CP107; p107; PRB1
ACCN	NM_183404
Insert Size	149 bp
Sequence Data	Insert Sequence (showhide) >SC203041 3’UTR clone of NM_183404 The sequence shown below is from the reference sequence of NM_183404. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAAC TGTTAATCCTGCCTCTTTTTTTTTTTTTCTTTTTTGGCCAAGTTACTACTATACTAATAAAATATGAAA TGTTAACTATG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_183404.4
Synonyms	CP107; p107; PRB1
Summary	The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Locus ID	5933
MW	5.7

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