PEN2 (PSENEN) (NM_172341) Human 3' UTR Clone

Specifications

Product Data
Product Name	PEN2 (PSENEN) (NM_172341) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ACNINV2; MDS033; MSTP064; PEN-2; PEN2
ACCN	NM_172341
Insert Size	702 bp
Sequence Data	Insert Sequence (showhide) >SC201685 3’UTR clone of NM_172341 The sequence shown below is from the reference sequence of NM_172341. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCTTCACCATACCCCTGGGCACCCCCTGACAACTTCTGCACATACTGGGGCCCTGCTTATTCTCCCAG GACAGGCTCCTTAAAGCAGAGGAGCCTGTCCTGGGAGCCCCTTCTCAAACTCCTAAGACTTGTTTTCAT GTCCCACGTTCTCTGCTGACATCCCCCAATAAAGGACCCTAACTTTCGATACTGACTTCCTGGGATCTT TTAGAGGTTGAGGCATAAATGATTATTAATATTTAAAAACATCTGTTGAGAGCTTTGTACGAGGCTTAG TATTTAGACATGATGTACATTTTTTACAGTGCATACTACTCATAATCTTCTGAACTAGGAACTTTCCTG CTCAGGAAACTATTAGATGAGAAACTAAGAAAGGAATAGTGCTTCCATTTCTTTTTCTTTTTTCTTTTT TTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCAGCCAGGCTGGAGTGCAGTGGTAGGATCGGCCTAG TGCTTCCATTTCTAGGGGCTGTTATCCTGTACTGGTAGTCGTGAATTCAAAAATATAACTTTCCTACTG TGGGCTGCAGTATTCTCATCAGAAGTGTAGATCACGATGCTACTTCCTGGGATTTATCTGGACCAAGAC GTGTGACAAATGGAAGTTTCCCGTTTTCTGAAGGAAGTGTTGTCTGCAAAAATAAAAATAGTCAAGAGC TTTCTCAGAGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_172341.4
Synonyms	ACNINV2; MDS033; MSTP064; PEN-2; PEN2
Summary	Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Locus ID	55851
MW	26.9

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