DNase I (DNASE1) (NM_005223) Human 3' UTR Clone

Specifications

Product Data
Product Name	DNase I (DNASE1) (NM_005223) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DNL1; DRNI
ACCN	NM_005223
Insert Size	172 bp
Sequence Data	Insert Sequence (showhide) >SC201430 3’UTR clone of NM_005223 The sequence shown below is from the reference sequence of NM_005223. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CACTATCCAGTGGAGGTGATGCTGAAGTGAGCAGCCCCTCCCCACACCAGTTGAACTGCAGGAAGAGAG GACCCATCCTGCCACAGGACCCAGAAAAAAAGCCCAACACACACTCGGGTTAAGAAATACCTTTAAATT TAGGTAAATAAAGCTCAAGGAGGTGGGGCTGTCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005223.4
Synonyms	DNL1; DRNI
Summary	This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Locus ID	1773
MW	6.3

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