COQ6 (NM_182476) Human 3' UTR Clone

Specifications

Product Data
Product Name	COQ6 (NM_182476) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CGI-10; CGI10; COQ10D6
ACCN	NM_182476
Insert Size	701 bp
Sequence Data	Insert Sequence (showhide) >SC200949 3’UTR clone of NM_182476 The sequence shown below is from the reference sequence of NM_182476. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAACAGATTATGGCCTTTGCAAGCAAATGAGTACTCCTCTCCTAAAGAAAGATTACGTTGATGAAAAAG AACATCCTGCCCAGGACCCATCATACATATTTTCAAGATCTTATTTAATTTAATAAACTTACTTTACAT TAAAATTCTCTTTTTCTTCTTTGCTTAATGGGCCTGTGGCACCCAAATAATGAATGATAATTTGCTGTG AGGAGCGTATATTAGCCAGACCAAAGGAAAAAACTTCGAAGGAAGACTTACAATTTGGTTGAAAAGAGC TTTTTATTACTAAAAAACCCACAAGGTGCTGTCTCACTCATTTCCAGTTAATCATTTCTAAAGAGAAAA TTTACATTTTGTTTTTGTTTTAATGTTGGTCATAAATTTATACAGTTGTTTTTTGATAGAGGTAAGAAT TAGACTCGATGCATTTTTGTTAGAATTGCTGTTTAAATGTTAACATCAGAATGCAAATTAAATATAAAT TGCTTTAACCTTTGTTACAGGTATACTGGACTTTCTGAAAGGAAAACCAGGTCTCATTAATGCTAGTTA TTACTTTATCACAGCACCAGATTTCCATTTTATTTATGGTTCCTCTCTGGGACACCACTGTCGGTTTAA TAAAACAATAAATAATTCATTGCACAGATCCGAAGACCTCAGGAACCAGATCACAAGGGAAACCGATTA GCAGCAGAATT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_182476.3
Synonyms	CGI-10; CGI10; COQ10D6
Summary	The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]
Locus ID	51004
MW	27.6

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