Kindlin 2 (FERMT2) (NM_001135000) Human 3' UTR Clone

Specifications

Product Data
Product Name	Kindlin 2 (FERMT2) (NM_001135000) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
ACCN	NM_001135000
Insert Size	285 bp
Sequence Data	Insert Sequence (showhide) >SC200272 3’UTR clone of NM_001135000 The sequence shown below is from the reference sequence of NM_001135000. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACTGGGAAATCAAAATGGTAAACTCATAACAATGTTACTTGAATATAGTCCTTCTCTGATACAAATTA GTACATTAAGAATAAAAAGGCCTATAAATTCTGATGATTATTTGTACCACCACCTCTTAAAGTACAGAC AGACCATGGTTGACTATTCATTTCTCACTTAAATTTGCCTATTTCATAATTAGCCCAGTTACTAAAATT CTAAGTGCATAATTTGCTTAGAATGTTGCCTTTTTTGTCTTTCTGTAATGGATAAAGCCGATCTACTCT GAAATAGCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001135000.2
Synonyms	KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
Summary	Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.[UniProtKB/Swiss-Prot Function]
Locus ID	10979
MW	11.1

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