Chicken TGFB1 ELISA KIT (96 T)
CNY 3,200.00
货期*
3周
规格
Specifications
Product Data | |
Description | Chicken TGF-β1 Immunoassay |
Size | 96 T |
Format | 96-well strip plate |
Assay Type | Solid Phase Sandwich ELISA |
Assay Length | 4 hours |
Signal | Colorimetric |
Curve Range | 31.25-2000pg/ml |
Sample Type | Serum, plasma, Cell culture supernatant |
Sample Volume | 100 uL |
Specificity | This assay recognizes both natural and recombinant Chicken TGF-β1 |
Sensitivity | 6 pg/mL |
Reactivity | Chicken |
Interference | No significant interference observed with available related molecules. |
Components |
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Background | TGF-β1 (transforming growth factor beta 1) was first identified in human platelets as a protein with a molecular mass of 25 kilodaltons with a potential role in wound healing. TGF- β1, TGF- β2, and TGF- β3 all function through the same receptor signaling systems. They are members of the large TGF-β superfamily. TGF-β proteins are highly pleiotropic cytokines that regulate processes such as immune function, proliferation and epithelial mesenchymal transition. It was later characterized as a large protein precursor (containing 390 amino acids) that was proteolytically processed to produce a mature peptide of 112 amino acids .TGF-β activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins. Although different isoforms of TGFβ are naturally associated with their own distinct LAPs, the TGF-β1 LAP is capable of complexing with, and inactivating, all other Chicken TGF-β isoforms and those of most other species. Mutations within the LAP are associated with Camurati Engelmann disease, a rare sclerosing bone dysplasia characterized by inappropriate presence of active TGF-β1. |
Gene Symbol | TGFB1 |
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