Human CD5 ELISA Kit 1 x 96

Specifications

Product Data
Description	Human CD5 ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	4.5 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	31pg/ml-2000pg/ml
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of Human Soluble CD5
Sensitivity	5pg/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	sCD5 Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human sCD5 Standard (100ng/ml)|0.1 mL 100x Biotin conjugated Procalcitonin Detection Antibody|0.12 mL 100x Streptavidin-HRP|0.12 mL Assay Buffer|50 mL Serum Sample Diluent|15 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer|3 pieces
Background	CD5 is a 67 kDa type I glycoprotein which belongs to the Scavenger Receptor Cysteine-Rich family of receptors. It is expressed on the surface of T cells and in a subset of murine B cells known as B-1a. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli. A number of studies have reported that CD5 is involved in the modulation of antitumor responses. CD5 is a good immunohistochemical marker for T-cells. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma. CD5 is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia is associated with a poor prognosis. Some research data confirmed the prognostic value of CD5 expression in NSCLC. Natural soluble CD5 form (sCD5) is a N-glycosylated 52 kDa molecule present in normal human serum, which is released via proteolytic cleavage of membrane form during lymphocyte activation. Circulating sCD5 levels are increased in several autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus.
Gene Symbol	CD5
Standard Curve	Data image of Human CD5 ELISA Kit.

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