Human ST2 (IL-33R) ELISA Kit 1 x 96

Specifications

Product Data
Description	Human ST2 (IL-33R) ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	4 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	156pg/ml-10000pg/ml
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of Human ST2 (IL-33R)
Sensitivity	5.9pg/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	ST2 Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human ST2 Standard (500ng/ml)|0.1 mL 100x HRP conjugated ST2 Detection Antibody|0.12 mL Assay Buffer|40 mL Standard Diluent12 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer2 pieces
Background	Interleukin 1 receptor-like 1 (IL1RL1), also known as ST2, is a protein that in humans is encoded by the IL1RL1 gene. Two isoforms of ST2 were described in mammals: the membrane-bound ST2 (referred to as the ST2 receptor or ST2L), which provides the activation pathway, and the soluble ST2 (referred to as soluble ST2 or sST2) that originates from another promoter region of the il1rl1 gene and lacks the transmembrane and cytoplasmic domains. The ligand for ST2 is the cytokine Interleukin-33 (IL-33). There is clear correlation between T regulatory cell ST2 and Th2 specific transcription factor GATA3 expressions. Soluble ST2 is present in ST2+ T Regulatory cell. Releasing of sST2 into extracellular space cause neutralization of IL-33 and regulation of inflammation. ST2 Mutations have been linked to atopic dermatitis and asthma. The ST2 protein is also directly implicated in the progression of cardiac disease and is considered to be a cardiac biomarker. When the myocardium is stretched, the ST2 gene is upregulated, increasing the concentration of circulating sST2. The heart is subjected to greater stress in the presence of high levels of sST2. Binding of IL-33 to the ST2 receptor, in response to cardiac disease or injury, such as an ischemic event, elicits a cardioprotective effect resulting in preserved cardiac function.
Gene Symbol	IL1RL1
Standard Curve	Data image for ST2 ELISA Kit.

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