Human IL-12 ELISpot Pair, 10 x 96-well

Specifications

Product Data
Description	Human IL-12 ELISpot Pair, 10 x 96-well
Size	10 x 96 wells
Format	10 x 96-well
Assay Type	Enzyme-Linked ImmunoSpot (ELISpot)
Signal	Colorimetric
Specificity	Recognizes natural human IL-12. Specific to p70 heterodimer.
Cross Reactivity	No cross reactivity with other human cytokines
Components	ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Background	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Gene Symbol	IL12B

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