Human IL-10 ELISpot Pair, 10 x 96-well

Specifications

Product Data
Description	Human IL-10 ELISpot Pair, 10 x 96-well
Size	10 x 96 wells
Format	10 x 96-well
Assay Type	Enzyme-Linked ImmunoSpot (ELISpot)
Signal	Colorimetric
Specificity	Recognizes natural human IL-10
Cross Reactivity	No cross reactivity with other human cytokines. Cross reactivity with simian IL-10. No cross reactivity with viral IL-10.
Components	ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Background	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]
Gene Symbol	IL10

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