Human IL-10 ELISpot Set, 5 x 96-well (plates not included)

Specifications

Product Data
Description	Human IL-10 ELISpot Set, 5 x 96-well (plates not included)
Size	5 x 96 wells (plates not included)
Format	5 x 96-well (plates not included)
Assay Type	Enzyme-Linked ImmunoSpot (ELISpot)
Assay Length	3h after cell stimulation
Signal	Colorimetric
Specificity	Recognizes natural human IL-10
Cross Reactivity	No cross reactivity with other human cytokines. Cross reactivity with simian IL-10. No cross reactivity with viral IL-10.
Components	ELISpot Sets include capture and detection antibodies, Streptavidin - Alkaline Phosphatase conjugated, BSA, BCIP/NTB, and blocking reagent.
Background	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]
Gene Symbol	IL10

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