ALDH1L1 Mouse Monoclonal Antibody [Clone ID: UMAB45]

Specifications

Product Data
Clone Name	UMAB45
Applications	IF, IHC, WB
Recommend Dilution	IHC 1:100, IF 1:100
Reactivity	Human, Dog, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ALDH1L1 (NP_036322) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	98.6 kDa
Gene Name	aldehyde dehydrogenase 1 family member L1
Database Link	NP_036322 Entrez Gene 64392 RatEntrez Gene 100855730 DogEntrez Gene 10840 Human UniProt ID O75891
Background	The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Synonyms	10-fTHF; 10-FTHFDH; FDH; FTHFD
Reference Data
Protein Families	Druggable Genome
Protein Pathways	One carbon pool by folate

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