PAX5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA 1:5000-10000, WB 1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody is raised against a recombinant protein of PAX5 expressed in HEK293 cells
Formulation	Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
Concentration	Lot dependent; please refer to CoA along with shipment
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	paired box 5
Database Link	NP_057953 Entrez Gene 5079 Human UniProt ID Q02548
Background	This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Synonyms	ALL3; BSAP
Reference Data
Protein Families	Transcription Factors

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