NFkB p100 / p52 (NFKB2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human NFKB2
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	2.55 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	96.5 kDa
Gene Name	nuclear factor kappa B subunit 2
Database Link	NP_002493 Entrez Gene 18034 MouseEntrez Gene 309452 RatEntrez Gene 4791 Human UniProt ID Q00653
Background	This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Synonyms	CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p52; p100
Reference Data
Protein Families	Transcription Factors
Protein Pathways	MAPK signaling pathway, Pathways in cancer

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