Desmoglein 1 (DSG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human DSG1
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	1.99 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	113.7 kDa
Gene Name	desmoglein 1
Database Link	NP_001933 Entrez Gene 1828 Human UniProt ID Q02413
Background	This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Synonyms	CDHF4; DG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1
Reference Data
Protein Families	Druggable Genome

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