ATR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human ATR
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	1.36 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	301.2 kDa
Gene Name	ATR serine/threonine kinase
Database Link	NP_001175 Entrez Gene 245000 MouseEntrez Gene 685055 RatEntrez Gene 545 Human UniProt ID Q13535
Background	The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
Synonyms	FCTCS; FRP1; MEC1; SCKL; SCKL1
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Cell cycle, p53 signaling pathway

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