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RPE65 Mouse Monoclonal Antibody [Clone ID: OTI6C6]
CAT＃: TA815247S
RPE65 mouse monoclonal antibody,clone OTI6C6
Size: 100 ul
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Specifications
| Product Data | |
| Clone Name | OTI6C6 |
| Applications | WB |
| Recommend Dilution | WB 1:500-1:2000 |
| Reactivity | Human,Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment of human RPE65 (NP_000320) produced in E.coli. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Predicted Protein Size | 61.4 kDa |
| Gene Name | retinal pigment epithelium-specific protein 65kDa |
| Database Link | |
| Background | The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017] |
| Synonyms | BCO3; LCA2; mRPE65; p63; rd12; RP20; sRPE65 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Retinol metabolism |
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