Major Basic Protein (PRG2) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F11]

Specifications

Product Data
Clone Name	OTI2F11
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 17-222 of human PRG2 (NP_002719) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	25.23 kDa
Gene Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Database Link	NP_002719 Entrez Gene 5553 Human UniProt ID P13727
Background	The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Synonyms	BMPG; MBP; MBP1; proMBP
Reference Data
Protein Families	Secreted Protein
Protein Pathways	Asthma

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