Myotilin (MYOT) Mouse Monoclonal Antibody [Clone ID: OTI5E11]

Specifications

Product Data
Clone Name	OTI5E11
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombiant protein of human MYOT (NP_006781) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.2 kDa
Gene Name	myotilin
Database Link	NP_006781 Entrez Gene 9499 Human UniProt ID Q9UBF9
Background	This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008]
Synonyms	LGMD1; LGMD1A; MFM3; TTID; TTOD
Reference Data

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