CHMP5 Mouse Monoclonal Antibody [Clone ID: OTI5C7]

Specifications

Product Data
Clone Name	OTI5C7
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CHMP5 (NP_057494) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	24.4 kDa
Gene Name	charged multivesicular body protein 5
Database Link	NP_057494 Entrez Gene 76959 MouseEntrez Gene 297995 RatEntrez Gene 51510 Human UniProt ID Q9NZZ3
Background	CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). [supplied by OMIM, Mar
Synonyms	C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2; Vps60
Reference Data
Protein Pathways	Endocytosis

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