CTLA4 Mouse Monoclonal Antibody [Clone ID: OTI1E2]

Specifications

Product Data
Clone Name	OTI1E2
Applications	IF, WB
Recommend Dilution	WB 1:2000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CTLA4 (NP_001032720) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	15 kDa
Gene Name	cytotoxic T-lymphocyte associated protein 4
Database Link	NP_001032720 Entrez Gene 1493 Human UniProt ID P16410
Background	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Synonyms	ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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