BRCA1 Mouse Monoclonal Antibody [Clone ID: OTI5D10]
CAT#: TA802618
BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10)
Size: 30 ul
Formulation: Carrier-Free
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CNY 1,999.00
CNY 2,700.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | OTI5D10 |
Applications | IHC |
Recommend Dilution | IHC 1:150 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1151-1473 of human BRCA1 (NP_009225) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | BRCA1, DNA repair associated |
Database Link | |
Background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] |
Synonyms | BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Ubiquitin mediated proteolysis |
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抗体相关资料 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF802618 | Carrier-free (BSA/glycerol-free) BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) |
CNY 3,999.00 |
|
TA802618AM | BRCA1 mouse monoclonal antibody,clone 5D10, Biotinylated |
CNY 3,990.00 |
|
TA802618BM | BRCA1 mouse monoclonal antibody,clone 5D10, HRP conjugated |
CNY 3,990.00 |
|
TA802618S | BRCA1 mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) |
CNY 800.00 |