NUMB Mouse Monoclonal Antibody [Clone ID: OTI3H8]

Specifications

Product Data
Clone Name	OTI3H8
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-365 of human NUMB (NP_001005744) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	65.7 kDa
Gene Name	NUMB, endocytic adaptor protein
Database Link	NP_001005744 Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human UniProt ID P49757
Background	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms	C14orf41; c14_5527; S171
Reference Data
Protein Pathways	Notch signaling pathway

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