NFH (NEFH) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI7E4]

Specifications

Product Data
Clone Name	OTI7E4
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:2000
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 778-1020 of human NEFH (NP_066554) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Gene Name	neurofilament, heavy polypeptide
Database Link	NP_066554 Entrez Gene 24587 RatEntrez Gene 4744 Human UniProt ID P12036
Background	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
Synonyms	NFH
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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