Serum Amyloid A (SAA1) Mouse Monoclonal Capture Antibody [Clone ID: OTI2E4]
CAT#: TA600569
SAA1 mouse monoclonal antibody, clone OTI2E4
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CNY 2,600.00
CNY 4,250.00
货期*
2周
规格
经常一起买 (1)
Specifications
Product Data | |
Clone Name | OTI2E4 |
Applications | ELISA |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment of human SAA (NP_954630) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Predicted Protein Size | 13.5 kDa |
Gene Name | serum amyloid A1 |
Database Link | |
Background | Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis. Mature SAA1 consists of 104 amino acids with an apparent molecular weight of 12,500. Native SAA1 is a hexamer with each subunit assuming an antiparallel 4-helix bundle structure. SAA1 is highly inducible. Inflammatory cytokines such as IL-1β, IL-6 and TNF-α are major stimulants for hepatocyte expression of the SAA1 gene. Inducible expression of the acute-phase SAA genes involves the transcription factors C/EBP, NF-κB, AP2, SAF, Sp1 and STAT3. SAA1 has been a clinical indicator and reliable biomarker for inflammatory diseases, chronic metabolic disorders and late-stage malignancy. |
Synonyms | PIG4; SAA; SAA2; TP53I4 |
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