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Androgen Receptor (AR) Rabbit Monoclonal Antibody [Clone ID: OTIR20C9]
CAT＃: TA592771S
AR Rabbit monoclonal antibody
Size: 100 ul
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CNY 870.00
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Specifications
| Product Data | |
| Clone Name | OTIR20C9 |
| Applications | IHC |
| Recommend Dilution | IHC 1:200 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide corresponding to residues in the N-terminus of human |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1.00mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Predicted Protein Size | 99 kDa |
| Gene Name | androgen receptor |
| Database Link | |
| Background | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017] |
| Synonyms | AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM |
| Reference Data | |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
| Protein Pathways | Oocyte meiosis, Pathways in cancer, Prostate cancer |
Documents
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| TA592771 | AR Rabbit monoclonal antibody |
CNY 1,999.00 |
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