COX2 (PTGS2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:250-1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Formulation	20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Concentration	0.83mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prostaglandin-endoperoxide synthase 2
Database Link	NP_000954 Entrez Gene 19225 MouseEntrez Gene 5743 Human UniProt ID P35354
Background	COX2 (Cyclooxygenase-2. PGHS2) is an inducible dimeric enzyme belonging to prostaglandin G/H synthase family. COX2, similar to COX1, functions to form prostaglandins by catalyzing the synthesis of cyclic endoperoxides from arachidonic acid. COX2 expression is induced by lipopolysaccaride (LPS) and peptoglycan (PGN) and is highly expressed in activated marcophages. It has been implicated as a mediator of inflammation and a possible role in prostanoid signaling in activity-dependent plasticity (1). COX2 is considered as an ideal marker in immune response regulation studies and a therapeutic target against inflammatory diseases (2).
Synonyms	COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2
Note	This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway

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