HIF1 beta (ARNT) Rabbit Polyclonal Antibody
CAT#: TA590094
Rabbit Polyclonal HIF-1 beta Antibody
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CNY 5,302.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
CNY 9,998.00
CNY 4,840.00
Specifications
Product Data | |
Applications | ELISA |
Recommend Dilution | WB: 1:5000-1:20000; ELISA: 1:100-1:2000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | DNA immunization. This antibody is specific for the C Terminus Region of the target protein. |
Formulation | 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0 |
Concentration | 0.8781 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | aryl hydrocarbon receptor nuclear translocator |
Database Link | |
Background | Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. |
Synonyms | bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO |
Note | This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Pathways in cancer, Renal cell carcinoma |
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