MDMX (MDM4) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2C9]
CAT#: TA505734BM
MDM4 mouse monoclonal antibody,clone 2C9, HRP conjugated
Conjugation: Unconjugated Biotin
View other "OTI2C9" antibodies (4)
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CNY 3,990.00
CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
Product Data | |
Clone Name | OTI2C9 |
Applications | IF, WB |
Recommend Dilution | WB 1:2000, IF 1:100 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 54.7 kDa |
Gene Name | MDM4 regulator of p53 |
Database Link | |
Background | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
Synonyms | HDMX; MDMX; MRP1 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | p53 signaling pathway |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF505734 | Carrier-free (BSA/glycerol-free) MDM4 mouse monoclonal antibody, clone OTI2C9 (formerly 2C9) |
CNY 3,999.00 |
|
TA505734 | MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C9 (formerly 2C9) |
CNY 1,999.00 |
|
TA505734AM | MDM4 mouse monoclonal antibody,clone 2C9, Biotinylated |
CNY 3,990.00 |
|
TA505734S | MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C9 (formerly 2C9) |
CNY 800.00 |