GBA3 Mouse Monoclonal Antibody [Clone ID: OTI5G5]

Specifications

Product Data
Clone Name	OTI5G5
Applications	FC, IHC, WB
Recommend Dilution	WB: 1:200 - 1:1000, IHC 1:150, FLOW 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-150 and 370-469 of human GBA3(NP_066024) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.9 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	53.5 kDa
Gene Name	glucosylceramidase beta 3 (gene/pseudogene)
Database Link	NP_066024 Entrez Gene 57733 Human UniProt ID Q9H227
Background	GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]). [supplied by OMIM]
Synonyms	CBG; CBGL1; GLUC; KLRP
Reference Data
Protein Pathways	Cyanoamino acid metabolism, Starch and sucrose metabolism

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