HES1 Mouse Monoclonal Antibody [Clone ID: OTI4H1]

Specifications

Product Data
Clone Name	OTI4H1
Applications	IF, IHC, WB
Recommend Dilution	WB 1:1000; IHC 1:50; RPPA 1:75; IF (1:100)
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein expressed in E.coli corresponding to amino acids 1-280 of human HES1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29.4 kDa
Gene Name	hes family bHLH transcription factor 1
Database Link	NP_005515 Entrez Gene 15205 MouseEntrez Gene 29577 RatEntrez Gene 3280 Human UniProt ID Q14469
Background	This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Synonyms	bHLHb39; HES-1; HHL; HRY
Reference Data
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors
Protein Pathways	Maturity onset diabetes of the young, Notch signaling pathway

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