NOTCH1 Mouse Monoclonal Antibody [Clone ID: OTI3E12]
CAT#: TA500078S
Anti-Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12)
Size: 100 ul
View other "OTI3E12" antibodies (4)
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CNY 800.00
Cited in 2 publications. |
CNY 300.00
CNY 1,430.00
CNY 4,840.00
Specifications
Product Data | |
Clone Name | OTI3E12 |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1:1000; IHC 1;50; RPPA 1:75; IF: 1:100 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1 |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.2 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 270.6 kDa |
Gene Name | notch receptor 1 |
Database Link | |
Background | Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development |
Synonyms | AOS5; AOVD1; hN1; TAN1 |
Reference Data | |
Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway |
Protein Pathways | Dorso-ventral axis formation, Notch signaling pathway, Prion diseases |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Notch1 serves as a prognostic factor and regulates metastasis via regulating EGFR expression in hypopharyngeal squamous cell carcinoma
,Tian, J;Liu, X;Liu, X;Jing, P;Sa, N;Wang, H;Xu, W;,
Onco Targets Ther
,PubMed ID 30425527
[NOTCH1]
|
Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours
,Kenichi Harada, Yasunori Sato, Hiroko Ikeda, Maylee Hsu, Saya Igarashi, and Yasuni Nakanuma,
J. Clin. Pathol., May 2013; 66: 386 - 391.
,PubMed ID 23423517
[NOTCH1]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF500078 | Carrier-free (BSA/glycerol-free) Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12) |
CNY 3,999.00 |
|
TA500078 | Anti-Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12) |
CNY 1,999.00 |
|
TA500078AM | Notch1 mouse monoclonal antibody,clone 3E12, Biotinylated |
CNY 3,990.00 |
|
TA500078BM | Notch1 mouse monoclonal antibody,clone 3E12, HRP conjugated |
CNY 3,990.00 |