Cardiac Troponin I (TNNI3) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4E5]

Specifications

Product Data
Clone Name	OTI4E5
Applications	IF, WB
Recommend Dilution	WB 1:2500~5000, IF 1:50~100
Reactivity	Human, Dog, Monkey, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TNNI3 (NP_000354) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23.8 kDa
Gene Name	troponin I3, cardiac type
Database Link	NP_000354 Entrez Gene 21954 MouseEntrez Gene 29248 RatEntrez Gene 403566 DogEntrez Gene 698470 MonkeyEntrez Gene 7137 Human UniProt ID P19429
Background	Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Synonyms	CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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