Trem2 Rat Monoclonal Antibody [Clone ID: 78.18]

Specifications

Product Data
Clone Name	78.18
Applications	FC
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse TREM-2 Fc fusion protein
Specificity	TREM-2
Formulation	Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) Label: ALEXA FLUOR® 488,ALEXA FLUOR® 647,FITC,Low Endotoxin,Purified,RPE State: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant Purified IgG - liquid
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	+4°C, -20°C if preferred
Gene Name	triggering receptor expressed on myeloid cells 2
Database Link	UniProt ID Q99NH8
Background	Rat anti Mouse TREM-2 antibody, clone 78.18 recognizes triggering receptor expressed on myeloid cells 2 (TREM-2), an activating receptor of the Ig superfamily. TREM-2 forms a receptor signaling complex with DAP12 to trigger the activation of the immune response in macrophages and dendritic cells. It may be involved in chronic inflammation and may promote the production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 may also have a functional role in osteoclast formation.Stimulation of TREM-2 with Rat anti Mouse Trem-2 antibody, clone 78.18 enhances multinucleated osteoclast formation in vitro. Rat anti Mouse Trem-2 antibody, clone 78.18 may also be used to block TREM-2 on pre-osteoclasts to inhibit the formation of multinuclear osteoclasts and to inhibit bone resorption by mature osteoclasts.
Synonyms	TREM-2; Trem2a; Trem2b; Trem2c
Reference Data

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