NIPA (ZC3HC1) Rabbit Polyclonal Antibody
CAT#: TA392954S
NIPA (phospho-S354) polyclonal antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500~1:1000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Serine 354 |
Specificity | p-NIPA (S354) pAb detects endogenous levels of NIPA protein only when phosphorylated at Ser354. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 60-65 kDa |
Gene Name | zinc finger C3HC-type containing 1 |
Database Link | |
Background | Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation. |
Synonyms | hNIPA; HSPC216; NIPA; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC-type protein 1 |
Note | For research use only, not for use in diagnostic procedure. |
Reference Data |
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