NIPA (ZC3HC1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Serine 354
Specificity	p-NIPA (S354) pAb detects endogenous levels of NIPA protein only when phosphorylated at Ser354.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 60-65 kDa
Gene Name	zinc finger C3HC-type containing 1
Database Link	Entrez Gene 51530 Human UniProt ID Q86WB0
Background	Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation.
Synonyms	hNIPA; HSPC216; NIPA; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC-type protein 1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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