p38 (CRK) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human Crk2 around the phosphorylation site of Tyrosine 221.
Specificity	Crk2 (phospho-Y221) polyclonal antibody detects endogenous levels of Crk2 protein only when phosphorylated at Tyr221.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 34 kDa
Gene Name	v-crk avian sarcoma virus CT10 oncogene homolog
Database Link	Entrez Gene 1398 Human UniProt ID P46108
Background	Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
Synonyms	Adapter molecule crk; CRK; CRKII; p38 CRK; Proto-oncogene c-Crk
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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