PDK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:1000 IHC 1:50 - 1:100 IP 1:10 - 1:100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 260-322 of Human PDK2.
Specificity	PDK2 (R291) polyclonal antibody detects endogenous levels of PDK2 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 46 kDa
Gene Name	pyruvate dehydrogenase kinase 2
Database Link	Entrez Gene 5164 Human UniProt ID Q15119
Background	The core of PDC is composed of sixty dihydrolypoyl acetyltransferase (E2) subunits that bind directly to PDK2 and enhance PDK2 kinase activity. Upregulation of PDK isoenzymes occurs during starvation conditions, rerouting acetyl-CoA generation by facilitating fatty acid oxidation. PDKs contain five conserved regions and are mechanistically similar to bacterial His-kinases, in that both require histidine residues for activity. In mammals, transcripts for PDK2 are ubiquitously expressed with high levels in heart and skeletal muscle and decreased levels in spleen and lung.
Synonyms	isozyme 2; mitochondrial; PDHK2; PDK2; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase kinase isoform 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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