RAD21 Rabbit Polyclonal Antibody
CAT#: TA392794
Rad21 (D548) polyclonal antibody
Size: 25 ul
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CNY 1,999.00
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500~1:1000 IHC: 1:50~1:200 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 521-570 of Human Rad21. |
Specificity | Rad21 (D548) polyclonal antibody detects endogenous levels of Rad21 protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 130 kDa |
Gene Name | RAD21 cohesin complex component |
Database Link | |
Background | Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspaselike enzyme, allows chromosomal separation. Rad21 interacts with Rec8 to form a cohesin complex that functions in sister chromatid alignment. Rad21 is also involved in the repair of double-strand breaks in DNA and is essential for mitotic growth. Rad21 undergoes a C-terminal cleavage induced by diverse stimuli right before apoptosis. The cleavage product migrates to the cytoplasm and is involved in early events in the apoptotic pathway and it amplifiies the cell death signal in a positive-feedback manner. |
Synonyms | Double-strand-break repair protein rad21 homolog; hHR21; HR21; KIAA0078; Nuclear matrix protein 1; NXP-1; NXP1; RAD21; SCC1 homolog |
Note | For research use only, not for use in diagnostic procedure. |
Reference Data |
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