MDA5 (IFIH1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding Human IFIH1.
Specificity	IFIH1 polyclonal antibody detects endogenous levels of IFIH1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 135 kDa
Gene Name	interferon induced with helicase C domain 1
Database Link	Entrez Gene 64135 Human UniProt ID Q9BYX4
Background	IFIH1 (interferon induced with helicase C domain 1), also known as MDA5 (melanoma differentiation-associated protein 5), is one of a family of intracellular proteins known to recognise viral RNA and mediate the innate immune response. IFIH1 is causal in type 1 diabetes based on the protective associations of four rare variants, where the derived alleles are predicted to reduce gene expression or function.
Synonyms	CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; Helicard; Helicase with 2 CARD domains; IFIH1; Interferon-induced helicase C domain-containing protein 1; Interferon-induced with helicase C domain protein 1; MDA-5; MDA5; Melanoma differentiation-associated protein 5; Murabutide down-regulated protein; RH116; RIG-I-like receptor 2; RLR-2; RNA helicase-DEAD box protein 116
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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