HSP70-1A (HSPA1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide derived from human HSP70 around the phosphorylation site of Tyrosine 41.
Specificity	p-HSP70 (Y41) polyclonal antibody detects endogenous levels of HSP70 protein only when phosphorylated at Tyr41.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 70 kDa
Gene Name	heat shock protein family A (Hsp70) member 1A
Database Link	Entrez Gene 3303 Human UniProt ID P08107
Background	The HSP 70 family is composed of four highly conserved proteins: HSP 70, HSC 70, GRP 75 and GRP 78. These proteins serve a variety of roles: they act as molecular chaperones facilitating the assembly of multi-protein complexes, participate in the translocation of polypeptides across cell membranes and to the nucleus and aid in the proper folding of nascent polypeptide chains. All members of the family, except HSP 70, are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. HSP 70 and HSC 70 play key roles in the cytosolic endoplasmic reticulum and mitochondrial import machinery and are found in both the cytosol and nucleus of mammalian cells. Both HSP 70 and HSC 70 are involved in the chaperoning of nascent polypeptide chains and in protecting cells against the accumulation of improperly folded proteins. GRP 78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. It has been postulated that members of the HSP 70 family act as force-generating motors, relying on the hydrolysis of ATP for their activity.
Synonyms	Heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A/1B; HSP-70; HSP 70; HSP70-1/HSP70-2; HSP70.1/HSP70.2; HSPA1; HSPA1A; HSPA1B; HSX70
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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