NR2C2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000
Reactivity	Human, Pig
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human TR4.
Specificity	TR4 polyclonal antibody detects endogenous levels of TR4 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 67 kDa
Gene Name	nuclear receptor subfamily 2 group C member 2
Database Link	Entrez Gene 7182 Human UniProt ID P49116
Background	Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2. TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs). TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation. TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation. High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2. Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis.
Synonyms	NR2C2; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TAK1, TR4; Testicular receptor 4
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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