SQSTM1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IF: 1:50~1:200 IHC: 1:50~1:200 IP: 1:50~1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant full length Human SQSTM1.
Specificity	SQSTM1 polyclonal antibody detects endogenous levels of SQSTM1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 60 kDa
Gene Name	sequestosome 1
Database Link	Entrez Gene 8878 Human UniProt ID Q13501
Background	The chronic focal skeletal disorder, Paget’s disease of bone, affects 2-3% of the population over the age of 60 years. Paget’s disease is characterized by increased bone resorption by osteoclasts, followed by abundant new bone formation that is of poor quality. The disease leads to several complications including bone pain and deformities, as well as fissures and fractures. Mutations in the ubiquitin-associated (UBA) domain of the Sequestosome 1 protein (SQSTM1), also designated p62 or ZIP, commonly cause Paget’s disease since the UBA is necessary for aggregate sequestration and cell survival.
Synonyms	EBI3-associated protein of 60 kDa; EBIAP; ORCA; OSIL; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Sequestosome-1; SQSTM1; Ubiquitin-binding protein p62
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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